Dr. Kishore B. Challagundla
Department of Biochemistry & Molecular Biology,University of Nebraska Medical Center,USA
Kishore Challagundla earned his PhD in Biochemistry from Lucknow University in 2007. Kishore Post-Doctoral training on the role of TRAIL signaling in inducing hepatic damage during HIV/HCV co-infection with Dr.Stacey Rizza at the Mayo Clinic in Rochester and the laboratory of Dr.Mushui-Dai at Oregon Health & Science University in Portland exploring the mechanistic insight into the regulation of p53/Myc by ribosomal proteins. Later Kishore moved to Children's Hospital Los Angeles as a Research Associate in the laboratory of Dr.Muller Fabbri. Currently, Kishore is an Assistant Professor in Fred & Pamela Buffet Cancer Center at the University of Nebraska Medical Center in Omaha. Kishore's lab is investigating the role of exosomes and non-coding RNAs in inducing immunotherapy resistance, metastasis and to develop novel therapeutic strategies and biomarkers in pediatric cancers. His lab also investigates on the post-translational modifications of PD-L1 by ubiquitination/deubiquitination and their potential role in escaping immune surveillance.
Exosomes, Non-coding RNAs, Immunotherapy, Therapy resistance, Biomarkers, Cancer Stem cells, Metastasis