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Polymer Chemistry 2018
Polymer Sciences
ISSN: 2471-9935
Page 49
March 26-28, 2018
Vienna, Austria
3
rd
Edition of International Conference and Exhibition on
Polymer Chemistry
L
iposomes are widely used in medicine for encapsulation of
biologically active compounds. Multi-liposome assembly
composed of liposomes loadedwith different fillings could enable
controlleddeliveryofthemedicinesinadesirableratio.Inthiswork,
we suggest a universal approach for preparation of biodegradable
multiliposomal containers through electrostatic adsorption of
liposomes on the surface of polymer nanoparticles. Firstly, we
describe the preparation and properties of nanoconjugates with
the “core-shell” structure in which the micellar core from a block
copolymer of polylactide and polyoxyethylene is covered by a
monolayer of small unilamellar liposomes. It was shown that
one micelle could bind 5–6 anionic liposomes. The resulting
nanoconjugate was stable in a physiological solution with [NaCl]
= 0.15 M. At the same time, the nanoconjugate degraded, being
attacked by proteolytic enzymes, down to 10–15 nm particles,
that was accompanied by a complete release of the encapsulated
antitumor antibiotic doxorubicin into surrounding solution. In
the second part of the study, anionic liposomes were adsorbed
on the surface of cationic chitosan nanoparticles. Chitosan is a
commercially available polycationic biopolymer of natural origin
that is known for being biocompatible and biodegradable. Each
chitosan particle could adsorb up to 100 anionic liposomes.
The conjugates demonstrated stability towards dissociation
in physiological media. The complexes were biodegradable,
which eventually decomposed after addition of enzymes. It was
found that chitosan-liposome complex and the products of its
biodegradation were non-toxic in a wide range of concentrations.
Thus, the findings of this work seem to be promising in the field
of drug delivery. This work was supported by the Russian Science
Foundation (project no. 14-13-00255).
Recent Publications
1. Yaroslavov A A, Efimova A A, Rudenskaya G N, Melik-
Nubarov N S, Grozdova I D,
et al.
(2017) An electrostatic
conjugate composed of liposomes, polylysine and a
polylactide micelle: a biodegradability–cytotoxicity
relationship. Mendeleev Communications 27(3):299.
2. Sybachin A V, Zaborova O V, Efimova A A, Ballauff M and
Yaroslavov A A (2017) Electrostatic complexes of liquid
and solid liposomes with spherical polycationic brushes.
Polymer Science-Series C 59(1):60.
3. Efimova A A, Chvalun S N, Kulebyakina A I, Kozlova E V
and Yaroslavov A A (2016) Synthesis and properties of
conjugates involving liposomes, a linear polymer, and
the micelle of a polylactide–poly(ethylene glycol) block
copolymer. Polymer Science-Series A 58(2):172.
4. Efimova A A, Zaborova O V and Sybachin A V (2016)
Multiliposomal nanocontainers based on anionic solid
liposomes and spherical polycationic brushes. Materials
Science and Engineering 1(111):22.
5. Efimova A A, Sybachin A V, Chvalun S N, Kulebyakina A I,
Kozlova E V,
et al.
(2015) Biodegradable multiliposomal
containers. Polymer Science-Series B 57(2):140.
Biography
Anna A. Efimova graduated from Faculty of Chemistry, M.V. Lomonosov
Moscow State University. In 1996 defended Ph.D. thesis. Since 1996- Re-
search Scientist, since 2008- Associate Professor at Polymer Department
of Moscow State University. In 2004 awarded with the certificate of honour
of the Ministry of Education. Author or co-author of more than 40 scientific
publications. Research interests are associated with the interaction of poly-
mers and interpolymer complexes with colloid and liposomal dispersions,
structural rearrangements in lipid bilayers under the polymer adsorption,
polymer-induced transport of small molecules through the lipid membrane,
adsorption of liposomes on the surface of (bio) colloids, biodegradable and
stimuli-sensitive multiliposomal containers for the immobilization of biolog-
ically active substances..
ephimova@genebee.msu.suNanocontainers based on biodegradable polymer and anionic
liposomes
Efimova A A, Mulashkin F D, Krivtsov G G, Melik-Nubarov N S, Grozdova I D,
Rudenskaya G N, Sybachin A V, Chvalun S N, Kulebyakina A I, Razuvaeva E V
and
Yaroslavov A A
Lomonosov Moscow State University, Russia
Efimova A A et al., Polym Sci, Volume 4
DOI: 10.4172/2471-9935-C1-008