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Pharmacognosy 2019
March 11-12, 2019
London, UK
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 16
Mining plants and microorganisms for
biologically active compounds: A combined
synthetic and analytical approach
Niko Radulović
University of Niš, Serbia
N
ature offers an inexhaustible pool of biologically
relevant molecules crafted by evolution and
working in unison. Extensive analyses of mixtures of
naturally occurring molecules of plant and microbial
origin enable us to locate the possible organisms for
bioprospecting or biotechnological utilization. However,
the classical approaches leave much unidentified and
untested compounds especially when it comes to
minor constituents. Numerous challenges make low
abundance metabolites an unattractive target that
requires the application and development of innovative
analytical methodologies. We have repeatedly
demonstrated that organic synthesis offers a new
approach to the identification and biological evaluation
of secondary metabolites. Coupled with an array of
in vivo
and
in vitro
pharmacological and toxicological
assays, the creation of small synthetic libraries of
compounds and the development/application of NMR
and GC-MS based techniques for the identification
stereo-chemical assignment of compounds directly
fromtheirmixtures, has provided us access to a number
of new leadmolecules fromplants andmicroorganisms
of medicinal or other interest. In this lecture, examples
of exploitation of such an analytical synthetic approach
will be conveyed with a specific emphasis on volatile
plant constitutes from medicinal species and those
regarded as functional food.
Biography
Niko S Radulović currently working as a Full Professor of Organic
Chemistry and Biochemistry in University of Niš, Serbia. He was also
a Principal investigator for “Combinatorial libraries of heterogeneous
catalysts, natural products, modified natural products and their ana-
logues: A path to biologically active agents”, funded by the Ministry
of Education, Science and Technological Development of Serbia.His
research interests include organic synthesis, medicinal chemistry,
phytochemistry, NMR, HiFSA-ASIS-GIAO NMR-based methodologies,
biologically active compounds, structure-activity relationship.
Niko Radulović, Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-007