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E u r o S c i C o n C o n f e r e n c e o n
PEDIATRICS
2017
Pediatrics 2017
Volume:3 Issue:4(Suppl)
Journal of Pediatric Care
ISSN 2471-805X
N o v e m b e r 1 3 - 1 4 , 2 0 1 7
L o n d o n , U K
Page 15
Three types of brain arteriovenous vascular malformations have been
described in children and are classified according to their anatomical
location. Vein of Galen malformations located in the choroidal tissue of the
roof of the third ventricle are the most frequent type. The remaining two are
pial arteriovenous malformations located under the pia matter and dural
arteriovenous malformations located in the dura. Sometimes, they remain
asymptomatic, but often they can be associated with a wide range of symptoms
related either to their angio-architecture or to their hemodynamic changes on
the brain. Clinical presentations range from heart failure in high-flow arterio-
venous malformations or hydrocephalus to subacute or chronic brain lesions
related to local or regional venous hypertension. Additionally, venous reflux
can expose the patients to brain haemorrhage. Some paediatric arteriovenous
vascular malformations have been associated with various genetic mutations:
Rendu-Osler-Weber disease or CM-AVM1 (RASA1 mutation) and CM-AVM2
(EPHB4 mutation), each of which are related to a specific phenotype. The
treatment options for these vascular malformations are primarily endovascular
with transarterial or transvenous embolization, depending on the angio-
architecture and the type of lesion. A specific treatment strategy and schedule
will be determined according to the type of malformation and its potential local
or general effects on the brain. Ignoring the therapeutic window may lead to
severe brain damages. The aim of this presentation is to provide an overview of
the management of these arteriovenous malformations including the genetic
findings, therapeutic strategies and timing of treatment in these particularly
weak patients.
Biography
Guillaume Saliou is currently the Head of the Interventional Neu-
roradiology Unit at Lausanne University Hospital, Switzerland.
He is the former Head of the Paediatric and Adult Intervention-
al Neuroradiology Unit in Bicêtre Hospital in France. He has
completed his Postdoctoral qualification at Paris-XI University
School of Medicine. He has published several papers in reputed
journals and has been serving as an Editorial Board Member in
the field of pre- and post-natal management of cerebrovascular
diseases.
Optimal management of pediatric cerebral
arteriovenous malformations
Guillaume Saliou1,2
1Lausanne University Hospital, Switzerland
2Bicêtre Hospital, France
Guillaume Saliou, J Pediatr Care 2017, 3:4(Suppl)
DOI: 10.21767/2471-805X-C1-002