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I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
Nuclear Medicine & Radiation Therapy 2018
Page 31
Biography
Carola Kryschi has completed her PhD in Physical Chemistry
from Heinrich-Heine University of Duesseldorf and Postdoc-
toral research studies from Stanford University. In 1993, she
accomplished her habilitation thesis in Experimental Physics
and became an Assistant Professor of Experimental Physics
at Heinrich-Heine University of Duesseldorf. Since 2000, she
is University Professor of Physical Chemistry at Friedrich-Alex-
ander University of Erlangen. She has published 2 patents and
more than 100 scientific papers in peer reviewed internation-
al journals and had been serving as a Peer Reviewer for more
than 30 scientific journals in Physics, Physical Chemistry, La-
ser Spectroscopy, Material Sciences, Biochemistry, Biophysics,
Nanotechnology, Nanomedicine, Nanotoxicology and for the
Volkswagenstiftung, USA; Department of Energy and Deutsche
Forschungsgemeinschaft. Her current research interests are in
Nanotechnology, Nanoplasmonics, Ultrafast Laser Spectrosco-
py, Nanomedicine and Nanooncology.
carola.kryschi@fau.deMagneto-plasmonic nano-heterostructures
as X-ray dosage booster in radiation therapy
Carola Kryschi and Stefanie Klein
Friedrich-Alexander University of Erlangen Nurnberg, Germany
Carola Kryschi et al., J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-001
O
ur primary research objective is to design magnetically targeted magneto-
plasmonic nano-heterostructures (MP-NHs) that perform as multimodal
nanotherapeutics for synergistic cancer therapies. Therefore superparamagnetic
iron oxide nanoparticles (SPIONs) were merged with gold nanospheres,
nanoclusters or nanopatches, either through a thermal decomposition procedure
or via a facile co-precipitation synthesis. SPIONs with sizes around 20 nm were
shown to exhibit superparamagnetism as well as to develop substantial potential
as X-ray dosage enhancer when internalized by tumor cells. The Au-SPION nano-
heterodimers combine high-Z material with catalytically active Fe
3
O
4
surfaces and
moreover, plasmonic properties with superparamagnetic performance. In case of
the SPIONs, the interaction with X-rays creates through ablation highly reactive
surfaces. The freely accessible Fe
2+
and Fe
3+
ions may efficiently catalyze in the
cytoplasm with the generation of reactive oxygen species (ROS), in particular,
the formation of highly reactive hydroxyl radicals (via the Fenton reaction). As
boosting the ROS concentration in X-ray irradiated tumor cells for several 100%,
SPIONs display a high performance as X-ray dose enhancer. For NOBF4 stabilized
Au-SPION nano-heterodimers, we could verify synergistic interactions between
X-radiation and both kinds of surfaces composed either of Au atoms or Fe3O4,
which resulted in the simultaneous and independent formation of the nitric oxide
radical at the Fe
3
O
4
surface and the superoxide radical at the Au surface. The
surface-confined reaction between these radicals generated peroxynitrite. This
highly reactive species were observed to cause nitration of mitochondrial proteins,
lipid peroxidation, and induces DNA strand breakages. As providing a synergistic
nanoplatform for X-ray induced formation of both, the highly reactive radical nitric
oxide, superoxide and peroxynitrite, the NOBF
4
functionalized Au-SPION nano-
heterodimers were shown to exhibit excellent performance as X-ray enhancing
agents in radiation therapy.