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ISSN:2171-6625
September 18-19, 2017 | Dallas, USA
4th International Conference on
NEUROLOGY AND NEUROIMMUNOLOGY
Background: Cerebral palsy is a common pediatric problem
encountered in about 1:3 per 1000 born children and causing
variable mental, motor and behavioral dilemmas. Newly
introduced trials of neurogenesis with different agents are
now extensively evaluated.
Objective: Our study was conducted to evaluate the
neurotrophic response to B12 vitamin and omega-3 fatty
acids in children diagnosed early with variable forms of
cerebral palsy. The response was monitored both clinically
and with CT scan as being a highly predictive tool for
assessing cerebral palsy.
Design: The study was carried out on 40 cerebral palsy
patients; 26 (65%) out of them were girls, and 14 of them
were boys, aged from 0 to 5 years old; from outpatient clinic
at Zakho/Duhok General Hospital in Kurdistan Region-Iraq.
Patients were treated and followed up for 6 months to one
year. They were represented and adjusted by full history
taking and clinical examination. Brain CT scans were done for
every patient to assess the degree of brain atrophy before
starting this combined therapy, and every month for six
months to one year. There was an improvement in general
health of children after interventional therapy.
Results: The study revealed that early intervention of both
omega 3 and B12 vitamin in children under 5 with cerebral
palsy (CP) shows great response based on clinical examination
and CT scan findings. Almost, after combined therapy, 80%
of children with delayed speech have very good response
and improvement, 77% of children with delayed milestone
and hypertonia, and 87% with delayed walking have positive
clinical outcomes. Both sexes have equal response to
combined therapy. Such findings were obtained as a result of
early treatment and diagnosis of children with CP. In addition,
among the treated children with CP, improvement in CT scan
results was obtained. 84% of treated children have great
improvement in their neuroimaging results from moderate/
severe forms of brain atrophy to mild form of brain atrophy
after being treated and followed up for 6 months - 1 year.
Conclusion: The damaged brain sites based on CT scan
results, showed progressive improvement in response to B12
and omega-3 fatty acids upon daily supplement throughout
6 months to one year. However, combining these 2 drugs
showed preservative synergistic consequences. B12 vitamin
and omega- 3 fatty acids are valuable therapy for children
with various forms of cerebral palsy particularly when being
linked. The greatest improvement in speech and motor
development was significantly observed in about 32 patients
(80%) of treated children with B12 vitamin and omega- 3
fatty acids. Others have less response to combined therapy
as being presented and diagnosed beyond 1 year of age
(16%).
e:
The positive clinical consequence of early intervention of combined therapy (omega 3 fatty acids and
B12 vitamin) in children under 5 with variable forms of cerebral palsy
Khajik Sirob Yaqob
Zakho General Hospital, Iraq
J Neurol Neurosci, 8:5
DOI: 10.21767/2171-6625-C1-003