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Volume 4
Journal of Pediatric Care
ISSN: 2471-805X
Page 10
May 07-08, 2018 Frankfurt, Germany
&
JOINT EVENT
3
rd
International Conference on
Pediatrics and Pediatric Surgery
22
nd
Edition of International Conference on
Neonatology and Perinatology
Ryszard Lauterbach
Jagiellonian University, Poland
Ryszard Lauterbach, J Pediatr Care, Volume 4
DOI: 10.21767/2471-805X-C2-007
Non-activated protein C in treatment of neonatal sepsis
Background: Previously, we found that plasma protein C activity ≤10% significantly increased the probability of the occurrence
of death during neonatal sepsis. Thus, if the activity of plasma protein C declined during the course of sepsis to ≤10%, we
administered a non-activated protein C zymogen to increase a protein C activity. The aim of that retrospective analysis was to
explore treatment effects of protein C zymogen (PC) supplementation in septic infants, with plasma protein C activity ≤10%.
Methods: A database was used to locate 85 newborns treated with PC from among 458 analyzed infants with confirmed sepsis.
Results: The median birth weight and gestational age of treated infants were, respectively 1010.0 g and 29 weeks. In 47 infants,
early-onset sepsis (EOS) developed whereas in 38 neonates late-onset sepsis (LOS) was recognized. PC was given as a single
dose of 200 IU/kg. Among 458 septic patients, death occurred in 19 newborns (4.2%), exclusively in infants with plasma
protein C activity ≤10%. In 15 infants, death occurred in the course of EOS and 4 newborns died of LOS (EOS versus LOS;
p=0.036; Chi-square with the Yates correction).
Conclusions: An increased risk of death in septic neonates with plasma protein C activity ≤10% suggests the necessity for its
evaluation and possibility of supplementation of protein C zymogen.
Biography
Ryszard Lauterbach has completed his PhD and Postdoctoral studies from Jagiellonian University Medical College in Kraków. He is the Head of Department of Neona-
tology, Jagiellonian University Medical College and Vice-President of Polish Neonatal Society. He has published more than 75 papers in reputed journals and has been
serving as an Editorial Board Member of repute.
ryszard@lauterbach.pl