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Mass Spectrometry 2019
March 04-05, 2019
Berlin, Germany
Mass Spectrometry
9th Edition of International Conference on
International Journal of Drug Development and Research
ISSN: 0975-9344 Page 16
Mass spectrometry: Clinical artificial
intelligence application
Mahmoud Abdel Wahed Rafea
Zrythra, USA
Background: Erythrocytes Dynamic Antigens Store
(EDAS) is a new discovery. EDAS consists of self-
antigens and foreign (non-self) antigens. In patients
with infectious diseases or malignancies, antigens of
infection microorganism or malignant tumor exist in
EDAS.
Objective: Storing EDAS of normal individuals and
patients in a database has, at least, two benefits.
First, EDAS can be mined to determine biomarkers
representing diseases which can enable researchers
to develop a new line of laboratory diagnostic tests and
vaccines. Second, EDAScanbe querieddirectly, to reach
a precise diagnosis without need to do many laboratory
tests. The target is to find the minimum set of proteins
that can be used as biomarkers for a particular disease.
Methods: A hypothetical EDAS is created. Hundred-
thousand records are randomly generated. The
mathematical model of hypothetical EDAS together
with the proposed techniques for biomarker discovery
and direct diagnosis are described. Experiments by
generating case possibilities are conducted.
Results: Biomarkers proteins are identified for
pathogens and malignancies, which can be used to
diagnose conditions that are difficult to diagnose.
Conclusions: The presented tool can be used in clinical
laboratories to diagnose disease disorders.
Biography
Mahmoud Abdel Wahed Rafea completed his Graduation
from the Faculty of Medicine at Cairo University in 1975. He
completed his MSc in Clinical Pathology and Chemistry in
1980. He started studying computer science while working
as a clinical pathologist in 1984. He joined ARC (Agriculture
Research Center) in 1992. He got his PhD in Artificial Intel-
ligence from Cairo University. He worked as a Senior Re-
searcher in SICS (Swedish Institute of Computer Science)
from 2000-2002. He was promoted by ARC as a Full Profes-
sor in Computer Science, 2006. In 2009 and 2010 he worked
as a visiting Professor in Karolinska, Sweden. He discovered
that erythrocytes have a dynamic antigens store. In 2015,
he established the Erythrocytes Research Unit (ERU) under
ARC. He incorporated Erythra Corporation in 2018.
Mahmoud Abdel Wahed Rafea, Int J Drug Dev & Res 2019, Volume 11
DOI: 10.21767/0975-9344-C1-004