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Infectious Diseases
and STD-AIDS
Infectious Diseases and STD-AIDS 2018
Journal of Transmitted Diseases and Immunity
ISSN 2471-8084
A p r i l 2 6 , 2 7 2 0 1 8
R o m e , I t a l y
Page 55
J Transm Dis Immun 2018 Volume 2
DOI: 10.21767/2573-0320-C1-003
A
lthough there were some molecular epidemiology studies of Mycobacterium tuberculosis (Mtb) in Beijing, however, the study
on revealing the association between drug resistance and Beijing genotype was still lack. As a retrospective study, isolates
from patients with smear-positive tuberculosis were subjected to drug susceptibility testing (DST) and analyzed by spoligotyping
and variable number of tandem repeats (VNTR) typing. We analyzed association relationship by statistics methods. Among the
1189 Mtb strains Beijing genotype family was the dominated genotype. We found a significant difference between Beijing and
non-Beijing genotype strains when considering risk factors sex, age and registered residence. 849 (71.4%) strains were fully
sensitive to first-line drugs, while 340 (28.6%) strains were resistant to at least one of the drugs. Meanwhile, 9% (107/1189) was
MDR-TB. Statistics analysis results indicated that the frequencies of INH-resistance of Beijing genotype strains were significantly
lower than that of non-Beijing genotype strains. Our results indicated that there was a correlation relationship between Beijing
genotype and drug resistance only in INH. This study provided a broader profile of drug resistance levels and the distribution of
Mtb genotypes in Beijing.
liuyilotus@hotmail.comStudy on the association between Beijing genotype
Mycobacterium tuberculosis
and drug-resistance
Yi Liu
1
, Xuxia Zhang
1
, Yuqing Zhang
1
, Cong Yao
1
, Wei Wang
1
，Qing Xing
2
, Suming Wang
2
and Chuanyou Li
1
1
Capital Medical University, China
2
Beijing Research Institute for Tuberculosis Control, China