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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 106
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
M
ultiple sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, both genetic and environmental
factors contribute to the pathogenesis of the disease. The cholinergic system has been indicated as a mediator of neuro-
immune interactions, as well as an internal regulator of immune responses. The aim of the present research was to assess the
associations between butyryl cholinesterase (BChE) and acetyl cholinesterase (AChE) genetic variations, serum cholinergic and
inflammatory profiles in 102 relapsing remitting (RR) MS patients and 117 healthy controls. Results showed that in patients and
controls, the reduction of BChE enzymatic activity in subjects carry the BChE polymorphic allele. Serum levels of BChE were
higher in RR-MS patients compared to HD subjects, resulting in reduced amounts of circulating ACh. An increased frequency of
the BChE K-allele in MS patients as compared to controls was found. The BChE-K-allele seems a promising marker to assess the
role of non-neuronal cholinergic system in regulating peripheral inflammation via ACh regulation. This study shed light on the
role of the non-neuronal cholinergic system in immune cells to better understand MS aetiology and progression. The cross-talk
between the periphery and the CNS could have a new undescribed crucial role for MS, regarded as a systemic disease.
mreale@unich.itButyrylcholinesterase and acetylcholinesterase
polymorphisms and serum cholinergic and
inflammatory profiles in multiple sclerosis patients
Marcella Reale
1
, Marco D’Aurora
2
, Marta Di Nicola
1
, Ada Maria
Tata
3
, Chiara D’Angelo
1
, Erica Costantini
1
and Valentina Gatta
2
1
G.d’Annunzio University, Italy
2
Center of Aging Sciences and Translational Medicine (CeSI-MeT), Italy
3
Center of Neurobiology Daniel Bovet, Sapienza University of Rome, Italy
Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003