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Volume 9 Journal of Neurology and Neuroscience
ISSN: 2171-6625
Page 63
JOINT EVENT
July 23-24, 2018 Birmingham, UK
&
24th International Conference on Neuroscience and Neurochemistry
26th Edition of International Conference on Clinical Psychology and Neuroscience
Antipsychotic-inducedextrapyramidal symptoms: pilot preventing searchof potential geneticpredictors
in Belarusian population
Innesa Haylaenka M1, Objedkov V G2, Gorgun O V2, Kandratsenka H1, Shatarnova T M1, Levdansky O D1 and Davydenko O G1
1Institute of Genetics and Cytology-National Academy of Sciences of Belarus, Belarus
2Belarusian Medical State University, Belarus
Background: The efficiency and safety of antipsychotic treatment for schizophrenia patients is still a challenge in clinical
psychiatry. Investigation of genetic predictors which are involved in antipsychotic response will help treatment optimization
and personalization.
Aim: To investigate associations of gene polymorphisms: DRD2 (rs1800497), CYP2D64, GSTM1, GSTT1, SLC6A4 (5HTTLPR),
COMT (rs4680), NAT2 (rs1799929), MDRI (rs1045642) with extrapyramidal side effects induced by antipsychotics.
Study: Our sample was obtained from an observational, cross-sectional trial of patient diagnosed with paranoid schizophrenia
and assessed for antipsychotic-induced Parkinsonism and akathisia symptoms using the extrapyramidal symptom rating scale.
Patients were divided into three clinical groups: akathisia side effects only (n=48): Parkinsonism side effects only (n=57), 3) no
extrapyramidal side effects (n=32). Statistical analyses were conducted in SPSS 22.0.
Results: There was a significant association of DRD2 rs1800497 with antipsychotic-induced Parkinsonism (χ2=62,549, р<0.05).
Patients with Parkinsonism demonstrated a higher frequency of the DRD2 rs1800497 А2А2 genotype. Antipsychotic-induced
akathisia showed more complex genetic contributions. Along with rs1800497 DRD2 (χ 2=19.02, р<0.05), rs3892097 CYP2D6,
and deletions in GSTM1 (χ 2=22,979, р<0.05) and GSTT1 (χ 2=19,379, р<0.05) were associated with akathisia.
Conclusions: According to the data obtained, mechanism of antipsychotic-induced akathisia may include influence of
dopamine receptors functioning (DRD2) and xenobiotic toxicity (GSTM1, GSTT1) which may be induced by antipsychotic
medication.
J Neurol Neurosci 2018, Volume 9
DOI: 10.21767/2171-6625-C2-012