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Page 26
December 06-07 , 2018
Amsterdam, Nether l ands
Journal of Neuropsychiatry
ISSN: 2471-8548 Alzheimer’s and Dementia 2018
1 3 t h W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
The emergence of zebrafish as a valuable model of vertebrate development
and disease physiology has been a milestone in the past three decades. It
has given us many profound insights into the cellular and molecular mechanisms
of numerous physiological phenomena and diseases. One of the most intriguing
eminences about zebrafish is its astonishing ability to regenerate its brain after
an injury. Proportionately, the area of the brain in adult zebrafish brain dedicated
to adult neural stem cells (aNSCs) is much higher than in the mammalian brain.
Also, the aNSCs in zebrafish brain are distributed throughout the rostrocaudal
axis. Consequently, zebrafish can endure and repair an injury in almost any part
of the brain. In contrast, mammalian brain owing to its limited number of stem
cells restricted to only a few brain regions has an abysmal regenerative ability.
This compels us to ask two fundamental questions: what cellular and molecular
mechanisms give zebrafish this extraordinary brain regenerative capacity? What
pieces of those mechanisms are missing in the case of mammals? If only we
could figure these out, it can direct us to new paths to the discovery of novel
and useful therapies for neurodegenerative diseases, traumatic brain injury,
stroke and other medical conditions involving the loss of neurons. But before
this anticipation can be translated into clinical practice, we have to go a long way
understanding the basics of brain regeneration in zebrafish.
Biography
Surendra Kumar Anand is a 2nd year PhD student from
the Laboratory of Cellular and Molecular Neurobiology
(Lab 215), SLS, JNU working under the supervision of Dr
Amal Chandra Mondal, Associate Professor, SLS-JNU.
He has published a review article and a research article
in reputed international journals. He won the best poster
award in 22nd International Conference on Neurology and
Neurophysiology, 2018, Rome, Italy. He was also awarded
the FENS and IBRO-PERC stipend to attend the Neural
Circuit Development and Plasticity course at Utrecht
Summer School, 2018, Utrecht, the Netherlands. Besides,
he has five poster presentations, one oral presentation
and volunteering experience in national and international
conferences and symposia.
Learning brain regeneration from zebrafish (Danio rerio)
Surendra Kumar Anand and Amal Chandra Mondal
Jawaharlal Nehru University, India
Surendra Kumar Anand et al., J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-002