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December 06-07 , 2018
Amsterdam, Nether l ands
Journal of Neuropsychiatry
ISSN: 2471-8548
Alzheimer’s and Dementia 2018
1 3
t h
W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
Background:
Alzheimer's disease (AD) is a progressive and degenerative Process in gray (GM)) and White (WM) matter of the
human brain. Recent studies have been focused on pre symptomatic microstructural changes that will assist the early diagnosis
of AD. To date Magnetic resonance imaging (MRI) based microstructural changes research looked into neuronal destruction in
gray matter whereas, there are fewer studies on white matter abnormality.
Methods:
Long term DTI data from the Alzheimer's disease Beginning in 2 database were used to test. (A): the within-group
microstructural white matter changes in Samples with AD and healthy controls at baseline and The first six months ; and (B): the
between-group microstructural changes differences in Samples with AD and healthy controls at both Time points.
Results:
(A): Within-group: longitudinal Tract-Based study disclose that Samples with AD and healthy controls both had
decreased fractional anisotropy (FA) and increased mean diffusivity (MD) with changes in the hippocampal cingulum exclusive to
the AD group.( B): Between-group: relative to healthy controls, Samples with AD had lower FA and higher MD in the hippocampal
cingulum, as well as the corpus callosum, internal and external capsule; corona radiata; posterior thalamic radiation; superior and
inferior longitudinal fasciculus; fronto-occipital fasciculus; cingulate gyri; fornix; uncinate fasciculus; and tapetum
Conclusion:
The results of current study highlight that sensitivity toward white matter microstructure is a promising target for AD
microstructural changes research. Further longitudinal studies on both white and gray matters are recommended to get a deeper
understanding of these microstructural processes.
alizadeh@matlabr.comMicrostructural changes revealed by diffusion
tensor imaging (DTI) in Alzheimer’s disease
Navid Sarmast Alizadeh
1
,Javad Sheikhi
2
, Kayvan Mahdavi
Khazaei
3
, Bahram Moazaami
4
, Mohammad Reza Hoseinshahi
5
1
MRI Physicist ,High-Tech Department Pars Hospital- Department of Imaging ,Imam Khomeini
University Hospital, Tehran University of Medical Science, Iran
2
MRI Physicist ,Shahid Beheshti University Hospital
3
High-Tech Department Pars Hospital ,Iran
4
High-Tech Department Pars Hospital, Iran
5
High-Tech Department Pars Hospital, Iran
J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-003