Paola Marcato

Paola Marcato
Senior Scientist, Department of Pathology, Dalhousie University, Canada
 
Biography
Breast cancer, cancer stem cells, precision medicine, biomarkers, shRNA screens, retinoic acid, DNA methylation, long non-coding RNA The breast cancer projects in my laboratory have the long-term goal of developing improved therapeutic strategies for breast cancer based on a precision medicine approach. We utilize both transcriptome and methylome profiling, and genome-wide functional assays (e.g. shRNA screens) to identify biomarkers which predict response to therapies. Using a combination of breast cancer cell line panels, patient-derived xenografts (PDXs), mouse tumor models, and analysis of published patient datasets, the potential biomarkers are validated.
 
Research Interest
Breast cancer, cancer stem cells, precision medicine, biomarkers, shRNA screens, retinoic acid, DNA methylation, long non-coding RNA The breast cancer projects in my laboratory have the long-term goal of developing improved therapeutic strategies for breast cancer based on a precision medicine approach. We utilize both transcriptome and methylome profiling, and genome-wide functional assays (e.g. shRNA screens) to identify biomarkers which predict response to therapies. Using a combination of breast cancer cell line panels, patient-derived xenografts (PDXs), mouse tumor models, and analysis of published patient datasets, the potential biomarkers are validated.