Journal of Cell and Developmental Biology

Babichenko Igor Ivanovich
Head of the Department of Pathologic Anatomy of RUDN University, Moscow, Russia.

Biography

Babichenko Igor Ivanovich Professor, M.D., Doctor of Science, Head of the Department of Pathologic Anatomy of RUDN University, Moscow, Russia. Babichenko I.I. was born on April 10, 1952 in Moscow. After graduation in 1975, the medical faculty of the Moscow Medical Stomatological Institute, was trained in postgraduate school and worked as an assistant in the same institute, in 1979 defended thesis for Ph.D. His thesis, done under the guidance of prof. T.S. Naumova was devoted to the integration effects of afferent impulses of the trigeminal nerve and auditory nerve in the cochlear complex nuclei. As the result, the inhibitory effect of afferent trigeminal impulses on neuronal activity and late waves of evoked potentials in cochlear nuclei was shown. In 1987, together with M.D. L.N. Dyachkova, a mechanism was described for the formation of synaptic contacts in vertebrates, from coated vesicles were expressed on the surface membrane of neurons, to formation of symmetrical and asymmetric synaptic contacts. In subsequent joint studies with Professor A.B. Poletaev, after the introduction of immune sera to brain-specific proteins into the bloodstream of pregnant rats, we were able to increase or decrease the ratio of symmetrical and asymmetric synaptic contacts in the brain of newborn rats. However, subsequent behavioral tests of adult rats with increased or decreased content of mature and immature synaptic contacts, revealed a decrease of learning process, compared to control. In subsequent studies, together with Professor I.B. Krasnov, of brain and synaptic contacts formation in rats developed under conditions of weightlessness was studied. It was revealed slowing of the brain and the synaptic contacts formation, and a humoral mechanism of such changes was suggested. Similar changes were studied in rats in conditions of protein-energy deficiency. In 1985-1986 years in Japan, under the guidance of Professor P.K. Nakane, Babichenko I.I. studied modern immunohistochemical techniques that are introduced into practical pathological anatomy. Using the method of electronic immunohistochemistry, various fragments of the insulin receptor were elucidated, the identity of the a-subunit of this receptor with the a-subunit of the receptor for insulin-like growth factor was found out. The localization of the latter on the cytoplasmic membrane of the tanycytes in the median eminence of the brain was indicated. By the deafferentation of the middle eminence of the rats? brain, due to introduction of sodium glutamate, the humoral mechanism of the insulin action on the secretion of brain releasing factors was shown. Such a mechanism can be based on a metabolic syndrome. In 1991 Babichenko I.I. defended doctoral thesis on early molecular changes in the hypothalamic region under various stressful influences. From 1997 to the present time head the department of pathological anatomy of RUDN University, from 2012 to the present time, the head of the laboratory of pathological anatomy in the Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russia. Currently, he performs researches of the role of papillomavirus infection in the development of hyperplasia, SIN and squamous cell carcinoma in the oral mucosa. Together with the scientists of the Institute of Bioorganic Chemistry Russian Academy of Sciences, the role of abnormal pigment epithelium-derived factor processing in progressive myopia has been shown. In a contact with the Department of Urology, RUDN University, it was shown, that in prostate cancer, balance between MMP-9 and TIMP-1 is disturbed, this leads to infiltrating growth of the tumor. Together with the doctors of the Central Clinical Hospital of the Russian Academy of Science, the study of the integration of mesh implants into living tissues has been conducted, it has been shown that titanium vacuum deposition of polypropylene mesh leads to a higher proliferative activity of fibroblasts and formation of more mature type- I collagen. At present, the role of pluripotent stem cells in the formation of head and neck tumors is being studied.

Research Interest

Stem cells, oncology, molecular biology.