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E u r o S c i C o n C o n f e r e n c e o n
Neurology & Neurological
Disorders
Neurology 2018
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
Page 80
Journal of Neurology and Neuroscience
ISSN: 2171-6625
Background:
Antiepileptic drugs (AED) considered to be the most effective
method of treat-ment of epilepsy, but they are not only ineffective in
pharmacoresistant forms, but also can make patient’s condition more severe.
It forced us to risk and at the first time in Uzbekistan tries to use ketogenic diet
in patients with epilepsy.
Materials & Methods:
We investigated the duration of pharmacoresistant
epilepsy in 7 children of Uzbek nationality aged from 2 to 9 at the first time
when treated by AED, then by glucocorti-coids and after the cancellation of
drugs and use only classic ketogenic diet. All of them were under the clinical
examination with use of MRI, EEG with video monitoring, and USD of liver and
gallbladder, ketone and glucose tests. In children 3 used only glucocorticoids;
in 4 children we used combination of hydrocortisone in dose 5 mg/kg and
AED. Proven ineffectiveness of AED and glucocorticoids allowed us to
prescribe them ketogenic diet with macronutrient ratio 4:1 that was counted
by ketocalculator. Every week parents provided ketone bodies analyses in
urine and measured glucose level in blood of children. Once a 3 months was
performed blood analysis by gas analyzer.
Results:
In all children on EEG was noted decreased epileptiform activity, but
much better re-sults were in patients without MRI changes. Convulsions were
under the control, there almost were not generalized seizures in patients with
Lennox-Gastaut, West and Landau-Kleffner syn-dromes. Cognitive functions,
when their impairment was the main symptom, also partially re-turned and
there was observed significant progress in psychical development and social
adapta-tion of children. There were no any cases of hypoglycemic coma.
Conclusion:
Ketogenic diet if followed correctly may significantly improve the
condition of pa-tients with pharmacoresistant forms of epilepsy
Biography
Tuychibaeva NM is an Assistant Professor, Neurologist at
Tashkent Medical Academy, depart-ment of Neurology and
Intermed Clinic City Child Diagnostics Center respectively. She
has completed her Bachelor’s degree (1990-1996) and Clinical
Fellowship in Adult Neurology (1996-1999) at Tashkent Medical
Academy, Uzbekistan. She obtained her PhD in Medicine
(March 29, 2007) on Clinical features of Consequence of light
cerebral trauma from Second Tashkent State Medical Institute.
She has done training courses on epilepsy, pediatric related
topics. The main fields of her clinical researches are neurology
and medical genetics. She has an expertise in epilepsy, but
now she is also interested in different movement disorders,
especially in childhood
nodira-1973@mail.ruTuychibaeva N and Porsokhonova K
Tashkent Medical Academy, Uzbekistan
Tuychibaeva N et al., J Neurol Neurosci 2018, Volume: 9
DOI: 10.21767/2171-6625-C1-009
Use of ketogenic diet in children with pharmacological resistant
forms of epilepsy