neuroimmunology-2017-keynote

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Page 14
ISSN:2171-6625
September 18-19, 2017 | Dallas, USA
4th International Conference on
NEUROLOGY AND NEUROIMMUNOLOGY
Notes:
The Herpes viruses are a group of species specific viruses
with very little ability to cross species. Humans are the
only known hosts for these viruses and they survive through
latency and periodic recrudescence. There are nine known
human Herpes viruses. Of these, 4, 6 and possibly 7 (EBV
and Roseola viruses) appear to be involved in autoimmune
disease. EBVhas been found in the joint lesions or rheumatoid
arthritis and, though controversial, has been reported in
multiple sclerosis (MS) plaques. Also, Herpes 4 has been
found in MS plaques. These Herpes viruses have the ability to
immortalize lymphocytes (6 B-cells, 6 and 7 CD4 + T-cells and
provide them resistance to elimination by apoptosis. Thus,
the thymus may be unable to eliminate them in the thymus
which is important in eliminating cells directed against self
thus permitting autoimmunity. In rheumatoid arthritis, EBV
is found in synovial tissues and is presumed to contribute to
the inflammatory response and destroying the lymphocytes
in the bone marrow and synovial tissues is usually effective
in controlling the disease. In this lecture we will discuss
the evidence for Herpes viral involvement in autoimmune
diseases and possible mechanisms by which they could
induce autoimmunity. In MS, a similar mechanism is likely to
be in play and anti-CD20 monoclonal antibodies (rituximab
and ocrelizumab) are effective therapies.
Speaker Biography
Dr. Robert M completed his MD degree at the age of 23 years from the University
of Tennessee. His internship and neurology residency were at Wayne State University
followed by fellowships at the Montral Neurological institute and Harvard University.
He has serrve on the faculty at Stanford Medica School, Johns Hopkins Medical School,
served as director of the Center for Brain Research, university of Rochester and at
Oregon health and Science University.and is now Professor Emeritus at Univeristy of
Mississippi.. He has published more than 100 papers in reputed journals and is the
founding editor of the International Journal of MS Care.
e:
Robert M Herndon
Mississippi State University, USA
The Role of Herpes Viruses in Autoimmune Diseases
Robet M Herndon, J Neurol Neurosci, 8:5
DOI: 10.21767/2171-6625-C1-001