Renal Tubular Acidosis is occurred when kidneys of an individual are unable to function smoothly this results in an accumulation of acid and acidify urination. RTA is the result of transport defects in the reabsorption of bicarbonate (HCO3-) ions , the excretion of hydrogen (H+) ions , or both. Based upon clinical and laboratory characteristics RTA classified in three types i.e. type 1(distal), type 2 (proximal) and type 4 (generalized). Impairment in hydrogen ion secretipon in distal tubule results in high acidic urination, i.e. (>5.5). The proximal tubule is the major site for reabsorption of filtered HCO3- produces urine of pH >7. Patient suffering from this mostly undergo alkali therapy which generally varies with type.