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Mimetic peptides based on promiscuous enzyme as asymmetric catalyst in Aldol and Michael reactions

Joint Event: 5th International Conference on Green Chemistry and Technology & 6th International Conference on Environmental Chemistry and Engineering
July 24-26, 2017 Rome, Italy

Saadi Bayat and Basyaruddin A Rahman

Universiti Putra Malaysia, Malaysia
Tofigh Daru Research and Engineering Company, Iran

ScientificTracks Abstracts: Trends in Green chem

DOI: 10.21767/2471-9889-C1-002


Biocatalysis has emerged as an elegant and green tool for modern organic synthesis due to its high efficiency, good selectivity and environmental acceptability. Although, an enzyme is capable of catalyzing a specific reaction effectively, some unexpected experimental results have indicated that many enzymes are catalytically promiscuous. Mimetic peptides based on enzyme as a kind of important chiral scaffold are broadly identified for their obvious advantages, diverse structures and ready accessibility. Based on promiscuous aldo-keto-reductase enzymes, several mimetic peptides were designed which were synthesized and tested as multifunctional organocatalysts in direct asymmetric aldol and Michael reactions. The asymmetric aldol and Michael reactions, as the most prominent carbon-carbon bond formation reactions, are the central study issues in the field of asymmetric synthesis. In this study, promiscuous aldo-ketoreductase (AKR) is used to catalyze aldol reaction between aromatic aldehydes and ketones. Good yield (up to 75%), moderate enantioselectivity (60%), and high diastereoselectivity (dr) up to 93/7 (anti/syn) were obtained. Several mimetic peptides from AKR’s active site were designed and synthesized as asymmetric catalysts in the aldol and Michael reactions. The corresponding aldol products were produced with high yields (up to 97%) and excellent diastereoselectivities (up to 99/1) and enantioselectivities (up to 99.9) under mild reaction conditions. These peptides exhibit excellent catalytic activity in terms of yield, diastereoselectivity and enantioselectivity. The secondary structures of peptide catalysts provide an understanding of their mechanism.


Saadi Bayat received his BSc in Applied Chemistry at Buali Sina University (Hamedan, Iran, 2000). He completed his Postgraduation with MSc in Organic Chemistry at Kharazmi University (Tehran, Iran, 2008). He had enrolled in PhD program at Department of Chemistry, Faculty of Science of University of Putra Malaysia (UPM), under supervision of Prof. Dr. Mohd Basyaruddin Abdul Rahman. The following year, he was offered scholarship from Graduate Research Assistance (GRA), UPM. Moreover, his research program focuses on mimetic peptide as asymmetric catalysis. He employed strategies that include organo-catalyst design, and the application of these approaches to construct asymmetric C-C bond forming and esters hydrolysis. He was as a Postdoctoral Research Fellow for a year (May 2014-June. 2015) in UPM. He has been selected to receive Endeavor scholarship from Australian Government and has joined Dr. Bellinda Abott in La Trobe University, Melbourne (July 2015-January 2016).

Email: [email protected]

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