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Archives in Cancer Research

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Concentration levels of IL-10 and TNF-α cytokines in patients with HPV DNA positive and negative cervical lesions

International Conference on Cancer Epigenetics and Biomarkers
October 26-28, 2017 Osaka, Japan

Husham Y M Ali Bayazed, Katan Sabir Ali and Jaladet M S Jubrael

University of Zakho, Iraq Hawler Medical University, Iraq Duhok university, Iraq

Posters & Accepted Abstracts: Arch Can Res

Abstract:

Objective: The present study was performed to assess the immune response in women with HPV DNA positive and negative cervical lesions. Methods & Patients: 80 women with cervical lesions (age range of 25-70 years) were studied. The lesions were cytologically classified into 4 groups: ASC-US (20), CINI (30), CINII-III (16) and cervical carcinoma (14) prior to HPV DNA detection. Estimation of IL-10 and TNF-�?± cytokines was performed via Enzyme linked immunosorbent assay (ELISA) technique in cervical secretions and serum and PCR screening kits were utilized to detect HPV DNA on cervical smears. Results: The detected levels of IL-10 (mean�?±SE) concentration in cervical secretions of patients with HPV DNA positive and negative states and control group were 88.73�?±16.90 pg/ml, 24.00�?±2.84 pg/ml and 8.27�?±0.59 pg/ml respectively with significant differences (p<0.05), while levels of TNF-�?± in cervical secretion of the studied groups were 12.18�?±3.49 pg/ml, 9.90�?±0.73 pg/ml and 7.90�?±0.87 pg/ml respectively with non-significant differences. The detected levels of IL-10 in cervical secretions of HPV DNA positive cases (88.73�?±16.90 pg/ml) were significantly higher than in the sera (13.69�?±2.41 pg/ml) (p<0.05), while the levels of TNF-�?± in their cervical secretions (12.18�?±3.49 pg/ml) was slightly raised than in their sera (11.59�?±3.14 pg/ml) with non-significance differences. Conclusions: A raised levels of both IL-10 and TNF-�?± in secretions of HPV DNA positive women with different cervical lesions were detected. However, the observed higher levels of IL-10 than TNF-�?± indicate down-modulation of tumor-specific immune response to HPV infected lesions via significant raised concentrations of the first cytokine than the second one. Therefore, this phenomenon seems to provide a tumor progressive microenvironment by the immunosuppressant properties of IL-10 with minimal antitumor activity of TNF-�?±.

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