Insights in Analytical Electrochemistry Open Access

Chemical constituents of the aerial parts of Ducrosia ismaelis

Joint Event:8^th Annual Congress on Analytical and Bioanalytical Techniques & 14^th International Conference and Exhibition on Pharmaceutical Formulations

August 28-30, 2017 Brussels, Belgium

Abubaker M A Morgan, Sang-Hyun Lee, Hae-Dong Jang, Sang-Un Park and Young-Ho Kim

Chungnam National University, Republic of Korea
Hannam University, Daejeon, Republic of Korea

Posters & Accepted Abstracts: Insights Anal Electrochem

Abstract:

Ducrosia species belong to the Apiaceae family, the members of which typically contain unusual and/or unique phytochemicals, especially coumarins. In traditional medicine, various Ducrosia species are used as analgesics, pain relievers and cold treatments. Antimicrobial, antimycobacterial, antifungal, central nervous system depressant, and antianxiety effects have been reported for several Ducrosia species, including D. anethifolia and D. ismaelis. D. ismaelis Asch. (commonly known as Haza or Geshea) is a perennial, herbaceous, and branched plant with a characteristic aromatic odor. The whole herb, especially its aerial parts, has been used in traditional medicines to treat skin infections and to repel insects and reptiles. A new pterocarpan glycoside, glycinol-3-O-�?²-D-glucopyranoside (1), and a new dihydrochalcone glycoside, ismaeloside A (2), were isolated together with 10 known compounds, including several flavonoids (3â�?�?8), lignans, and phenolic compounds (9-12), from the methanol extract of the aerial parts of Ducrosia ismaelis. The chemical structures of these compounds were elucidated from spectroscopic data (ESI-MS, HR-ESI-MS, 1D, 2D-NMR, UV. and FT-IR) and by comparison of these data with previously published results. The anti-osteoporotic and antioxidant activities of the isolated compounds were assessed using tartrateresistant acid phosphatase (TRAP), oxygen radical absorbance capacity (ORAC), and reducing capacity assays. Compound 12 exhibited a dose-dependent inhibition of osteoclastic TRAP activity with a TRAP value of 86.05�?±6.55% of the control at a concentration of 10 �?¼M. Compounds 1, 3-5, and 8 showed potent peroxyl radical-scavenging capacities with ORAC values of 22.79�?±0.90, 25.57�?±0.49, 20.41�?±0.63, 26.55�?±0.42, and 24.83�?±0.12 �?¼M Trolox equivalents (TE) at 10 �?¼M, respectively. All the compounds were isolated for the first time from a Ducrosia species.