Shradha Mukherjee

Shradha Mukherjee Shradha Mukherjee
Arizona State University, Tempe, Arizona, USA


Dr. Shradha Mukherjee earned her Ph.D. in Biochemistry at University of Houston, Houston, TX in 2011 where she deciphered key signaling pathways underlying retinal development and lead neurotoxicity. During her postdoctoral research at University of Texas Southwestern Medical Center, Dallas, TX, she asked how adult neural stem cells are activated during neurogenesis. Towards this goal she utilized mouse genetics, next generation sequencing, bioinformatics and imaging approaches. She found that transcriptional repressors tightly regulate ribosome biogenesis genes essential for neural stem cells activation, a role that was hereto underappreciated in the field. Since completing her postdoctoral research mid-2017 she has pursued her passion in big data analysis to help understand diseases and solve global health challenges. She currently works as independent genomic/health data scientist in multiple cross-functional collaborations and is in the Health Informatics program of Arizona State University, Tempe, AZ.

Research Interest

Molecular biology techniques (cDNA cloning, shRNA cloning, electroporation and transduction); Cell biology and biochemistry techniques (Western blot, qPCR, and coimmunoprecipitation); Confocal, fluorescent microscopy and flow cytometry; Animal surgery (brain and retina); Next generation sequencing (RNA-seq, ChIP-seq) analysis and large dataset management; Cluster computing and cloud computing (Cyverse and Galaxy); Statistical programming environment (R, RStudio), scripting language (Python) and UNIX; Variant analysis (FreeBayes, GATK); Public databases (IVY GAP, GTEx, TCGA, NCBI-GEO, EMBL-EBI etc.); Algorithms for genomics (Python and Jupyter notebook); Bioinformatics tools and analysis pipelines (Homer, DESeq, Samtools, Bioconductor, Cuffdiff, GSEA, NIH-DAVID, PANTHER etc.); Team oriented.