Editorial - (2021) Volume 5, Issue 3
Aissani Nadhem1*,Sebai Hichem1 and Abidi Anouer2
1University of Jendouba, Tunisia
2Unit Researches 03/UR/08-05, Pulmonary Fibrosis: Prevention & Treatment, Faculty of Medicine of Tunis, Tunis, Tunisia
Received Date: March 24, 2021; Accepted Date: March 25, 2021; Published Date: March 31, 2021
Citation: Nadhem A, Hichem S, Anouer A (2021) Impact of Birth Weight of Newborns on Mother's Food Habit During Pregnancy. A Case-Control Study. J Food Nutr Popul Health. Vol.5 No.3:e101.
We aimed in the present study to investigate the protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis as well as the involvement of oxidative stress in such protection. In this respect, adult male Wistar rats were used and divided into three groups of twenty each: control (NaCl, 0.9%), bleomycin, and bleomycin (4 mg/kg b.w.) + P. lentiscus oil (3 g/kg, b.w.). Animals were pretreated for 30 days before the induction of fibrosis by bleomycin and 1 weak after the induction of fibrosis. Chemical analysis by gas chromatography showed that flexed oil is riech on Linoleic and palmitic acids (70.6 and 24.7%, respectively). Our data demonstrated that P. lentiscus oil protected against bleomycin-induced fibrosis as evidenced by TGFβ immunostaining increase in lungs fibrocytes as well as inflammatory infiltrate. We also showed that acute bleomycin-induced fibrosis was accompanied by an oxidative stress in lung tissue as assessed by an increase of lipid peroxidation as well as antioxidant enzyme activities depletion such as superoxide dismutase (SOD) and catalase (CAT). More importantly, P. lentiscus oil treatment reversed all bleomycin-induced oxidative stress parameters disturbances. In conclusion, we suggest that P. lentiscus oil had potent protective effects against bleomycin-induced fibrosis due in part to its antioxidant properties.
