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Short Article - (2019) Volume 1, Issue 3

Fructooligosacchairde (Fos) can modulate gut satietogenic hormones, gut flora and induce weight loss in obese adults

Aparna Assudani and mini Sheth

Phd, Prebiotics and avoirdupois, maharajah Sayajirao University of Baroda, India

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Abstract

In India, the time of health transition has brought the twin burden of below and over-nutrition. Recent researches focuses on distinctive unconventional mechanisms of avoirdupois involving gut - brain axis, hindrance and treatment of avoirdupois. therefore this study was conducted with AN objective to look at the results of Fructooligosaccharide (FOS) supplementation on gut satietogenic hormones (GLP-1, GIP, PYY, Leptin, endocrine and Insulin), gut-flora (Bifidobacterium, eubacterium, eubacterium and Bacteroides), and measure measurements. A irregular, double-blind, placebo controlled trial with one hundred twenty young weighty grade –I subjects (25-35 yrs) was designed. They were every which way appointed to teams that received either 20g FOS/d or 20g dextrose/d for ninety days. measure measurements, fast plasma and feculent samples were collected at baseline and post intervention.

In India, the time of health transition has brought the twin burden of below and over-nutrition. Recent researches focuses on distinctive unconventional mechanisms of avoirdupois involving gut - brain axis, hindrance and treatment of avoirdupois. therefore this study was conducted with AN objective to look at the results of Fructooligosaccharide (FOS) supplementation on gut satietogenic hormones (GLP-1, GIP, PYY, Leptin, endocrine and Insulin), gut-flora (Bifidobacterium, eubacterium, eubacterium and Bacteroides), and measure measurements. A irregular, double-blind, placebo controlled trial with one hundred twenty young weighty grade –I subjects (25-35 yrs) was designed. They were every which way appointed to teams that received either 20g FOS/d or 20g dextrose/d for ninety days. measure measurements, fast plasma and feculent samples were collected at baseline and post intervention. Plasma samples for gut hormones were analyzed mistreatment Luminex x-MAP technology in sub sample of sixty subjects. ends up in experimental cluster discovered vital reduction in weight, BMI, WC, WHR and body fat by a pair of.55%, 2.45%, 2.51%, 3.11%, and 5.93% severally as compared to placebo cluster. constitution of (8.13%) and eubacterium (10.77%) was considerably multiplied, but vital reduction in constitution of eubacterium (1.87%) and bacteria genus (13.07%) was ascertained. vital increase in plasma level of gut satietogenic internal secretion GLP-1 (1.53%) and endocrine (17.33%) along-with reduction in Leptin (5.78%) and endocrine (5.83%) was additionally ascertained. Weight negatively correlative (p<0.001) with GLP-1(r = -0.729) and GIP (r = -0.603) and completely with eubacterium (r = zero.09, NS) and bacteria genus (r = zero.09, NS). Stepwise regression toward the mean portrayed GLP-1 as a robust predictor of avoirdupois (58.6%). Hence, FOS proves to be a promising supplement in causation weight loss by modulating gut satietogenic hormones and gutflora.

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