Figure 4.Inhibitor studies of the cAMP -induced Isc in CF murine duodenum. Analysis of the cAMP-induced Isc in the duodena from individual CF mice (4a) indicated a subpopulation of mice with robust responses to forskolin/IBMX (right). The effects of anion transport inhibitors on the cAMP-induced Isc response (4b) indicated that NPPB significantly reduced the Isc by 39% (n = 4 - 6). *Significantly different from Isc before treatment.