Figure 2. Effects of pancreatin (Creon®) on fat absorption in pancreatic exocrine insufficient minipigs. A. Coefficient of fat absorption (CFA) as a function of pancreatin dose (lipase FIP units). Values were determined after a 5-day total feces collection from 3 pancreatic exocrine insufficient minipigs (given 0, 8, 16 or 24 capsules of Creon® 10,000 minimicrospheresTM/ meal) and 3 control minipigs, fed twice daily with a 250 g meal for 7-10 days prior to and during feces collection. CFA (%) = 100 x ((g/day in feed – g/day in feces) / g/day in feed). B. Log dose-response effects of pancreatic lipase. The doses of pancreatic lipase which would have been necessary for complete normalization of the fat digestion process were estimated by extrapolating to 100% from the log doseresponse curve, depending on the fecal CFA obtained. One hundred and 0% effects correspond to the CFA observed in control minipigs (95.5±0.9%) and pancreatic exocrine insufficient minipigs (31.5±8.1%), respectively. These data are from [27].