Figure 7.a. A single band of 243 bp of p53 mRNA was detected from 8 to 20 weeks. The p53 mRNA expression was also strongest at 12 weeks. The GAPDH mRNA of 452 bp as an internal control was expressed in all pancreatic tissue. b. Serial changes of p53 mRNA expression as determined by semiquantitative analysis. Each point represents the mean±SEM of 6 observations. P values vs. previous time interval.