Figure 2. The non- canonical Hedgehog pathway A) Ptc forms a complex with the maturing promoting factor (Mpf), regulating cell progression into mitosis by inhibiting Cyclin B and D. B) TGF-ß up-regulates Gli1/2 through Smad-3. C) Crosstalks between the Wnt and Hh signaling pathways occur via Gli3-Repressorform (Gli3R), which inhibits ß-Catenin via forming a complex with Sufu.D) Smo directly regulates cell motility via GTPases.E) Gli1 regulates FAS and FAS ligand.