Figure 1: The different forms of human lithostathine. Lithostathine S2-5 is the generic name of the eleven glycosylated isoforms with 144 amino acids of lithostathine secreted by pancreatic acinar cells in the pancreatic juice. The in vivo trypsic-like hydrolysis of the Arg11 – Ile12 bond of the protein generates lithostathine S1 with 133 amino acids, the in vitro one lithostathine H1 and an N-terminal glycosylated undecapeptide (lithostathine H2). Lithostathine C is the 133 residue-isoform isolated from the pancreatic stones. (the zig-zag line represents the glycosidic chain on the Thr 5) (adapted from [13]).