Figure 6.Scatterplot of NDV-LS cytotoxicity in human pancreatic cancer cell lines in the presence of acetylated trypsin (n=13 to 17). The mean minimum cytotoxic doses for each cell type were low (ranging from 0.15 to 152) and are shown as horizontal lines here. Tumor lines derived from patients with cystic fibrosis (CFPAC-1 and Capan-1) were significantly less sensitive (P< 0.001, Kruskal-Wallis test) to killing by NDV-LS than were other pancreatic tumor lines either with or without acetylated trypsin. With acetylated trypsin, HPDE or HuFb cells were significantly less sensitive (P< 0.001, Kruskal-Wallis with Dunn’s multiple comparison tests) to killing than were Panc 10.05, PL45, PANC-1, SU.86.86, or BxPC3 cells. HUVEC cells were also significantly less sensitive (P< 0.01 Kruskal- Wallis with Dunn’s multiple comparison tests) to killing than were Panc 10.05, PANC-1, or PL45 cells. Without acetylated trypsin, HPDE or HuFb or HPDE or HEKn cells were significantly less sensitive to NDV-LS cytotoxicity as compared to Panc 10.05, PL45, PANC-1, SU.86.86, or BxPC3 cells (P< 0.01, Kruskal-Wallis with Dunn’s multiple comparison tests).