C.No. Substituent’s Position Mean IC50 ± SEa (µg/ml)   R R1 R2 R3 R4 1 - H Cl H 2.93 ± 0.08 2 - H Cl H 2.5 ± 0.27 3 - H Cl H 7.76 ± 0.42 4 - H Cl H 6.01 ± 0.13 5 - H Cl H 9.1 ± 0.10 6 - H Cl H 8.26 ± 0.06 7 - H Cl H 1.52 ± 0.04 8 - H Cl H 5.15 ± 0.07 9 - H OMe H 12.33 ± 0.88 10 - H OMe H 6.8 ± 0.11 11 - OMe OMe OMe 7.16 ± 0.10 12 - OMe OMe OMe 6.0 ± 0.05 13 - OMe OMe OMe 4.6 ± 0.15 14 - - OMe - 8.03 ± 0.2 15 - - OMe - 7.9 ± 0.26 16 - - OMe - 6.3 ± 0.15 17 - - OMe - 4.56 ± 0.54 18 - - OMe - 1.61 ± 0.34 19 - OMe OMe OMe 9.0 ± 1.04 20 - OMe OMe OMe 2.03 ± 057 21 - OMe OMe OMe 2.48 ± 0.37 22 - OMe OMe OMe 13.0 ± 0.26 23 - OMe H OMe 8.43 ± 0.24 24 - OMe OMe H 3.13 ± 0.29 25 17.03 ± 0.20 26 H H OMe H 6.92 ± 0.25 27 H H OMe H 6.9 ± 0.15 28 OMe H OMe H 2.37 ± 0.22 29 OMe H OMe H 7.68 ± 0.15 30 OMe H OMe H 2.95 ± 0.21 31 OMe H OMe H 5.98 ± 0.22 32 OMe H OMe H 6.7 ± 0.21 33 OMe H OMe H 3.38 ± 0.06 34 OMe H OMe H 1.1 ± 0.06 35 OMe H OMe H 7.22 ± 0.29 36 OMe H H OMe 5.53 ± 0.24 37 OMe H H OMe 6.13 ± 0.18 38 OMe H H OMe 10.1 ± 0.31 39 OMe H H OMe 3.26 ± 0.29 40 OMe H H OMe 6.36 ± 0.29 41 OMe H H OMe 12.73 ± 0.32 42 H OMe OMe H 2.91 ± 0.08 43 H OMe OMe H 4.96 ± 056 44 H OMe OMe H 5.16 ± 0.32 45 H OMe OMe H 6.28 ± 0.09 46 H OMe OMe H 7.34 ± 0.27 47 H OMe OMe H 5.85 ± 0.07 48 H OMe OMe H 5.04 ± 0.31 49 H OMe OMe H 3.5 ± 0.23 50 H OMe OMe OMe 4.7 ± 0.21 51 H OMe OMe OMe 7.6 ± 0.67 52 H OMe OMe OMe 8.15 ± 0.95

Table 1: List of substituent’s along with Mean IC50 Value for corresponding compound.