The negative side effects of Schizophrenia are characterized as lessened enthusiastic articulation and avolition. Alogia, anhedonia, asociality are scarcely any different side effects referenced in the DSM 5. The Management of negative manifestations stays hazy and has demonstrated troublesome. Atypical antipsychotics, for example, olanzapine, quetiapine, and more up to date age medications, for example, paliperidone were utilized in a couple of studies dependent on the understanding we have of the job serotonin plays in negative side effects. In an examination entitled Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS), Jones et al found that a correlation of run of the mill and atypical antipsychotics demonstrated no huge contrast in viability between a run of the mill and an atypical antipsychotic tranquilize. Another treatment proposition was the utilization of antidepressants, which was likewise found to have inadequate proof for use in the board.