Mohammad Ghaderi, Mahdieh Molanouri Shamsi, Mehdi Mahdavi, Sirvan Atashak, Lala Baghersad
The Effect of resistance exercise training on calcineurin signaling expression in skeletal muscle of diabetic rats was studied. Male Wistar rats were randomized to one of four groups: control (C), trained (T), STZ-induced diabetes (D), and (Streptozotocin ) STZ-induced diabetes plus training (DT). Diabetes was induced by the i.p. injection of STZ (Sigma), 55 mg/kg of body weight in a 0.1 M citrate buffer (pH 4.5). The results showed that, Typical Type 1(diabetes mellitus) DM hyperglycemia occurred in D and DT groups with increased fasting glucose (P<0.001). Moreover, diabetic and resistance training rats showed a significant decrease in total weight (P<0.001). Significant different observed among groups in expression of(Regulator of calcineurin1) RCAN-1 mRNA (P<0.05). As RCAN- 1(messenger ribonucleic acid) mRNA increased in T group compare to C group (P<0.05). There was a significant decrease of RCAN-1 mRNA in soleus muscle D group compared with C group (P<0.05). There was not difference in DT group compared with C and D groups (P>0.05).
