Absence epilepsy characterized by sudden and brief unconsciousness is a form of idiopathic generalized epilepsy that occurs in childhood. In this study, 104 Wag/Rij male rats were used. Animals were divided into 13 groups, oxytocine 80 nmol/kg, valproic acid 300 mg/kg, ethosuximide 200 mg/kg, magnesium sulfate 600 mg/kg, methylprednisolone 20 mg/kg and double-triple combination of these chemicals were intraperitoneally given to the groups. In all one drug administered groups, we recorded significant decrease in mean SWD. In addition to this, we observed a stronger reduction in mean SWD when the drugs were combined with oxytocine in double combination groups. For triple combination groups, when methylprednisolone was added to the groups, larger changes were seen in mean SWD (p<0.05). We conclude that oxytocine decrease the number of absence seizures, and the combination of oxytocin with other drugs increase anti-epileptic effects of the drugs.