Abstract

Polymeric carriers for drug delivery system: Comparison study of effects of chitosan derivative and 1st tier dendrimer on Methotrexate release

A comparative study of chitosan derivative with methionine (CM) and trimesoyl 1, 3, 5-tridipropyl malonate ester (TTDPM) as drug delivery vehicle encapsulated with the model drug ( Methotrexate: MTX) individually, for breast cancer drug delivery system. MTX-TTDPM and MTX-CM were prepared using a 1 : 1 ratio of MTX, TTDPM and MTX, CM in acetone and ionotropic gelation medium at RT followed by 24 and 3 h respectively. MTX interact with TTDPM and CM by hydrogen bonding confirmed through FTIR and further characterized by SEM, HR-TEM and DLS for their morphological and narrow particle size distribution respectively. TTDPM and CM has functionality which assistances to bind MTX anticancer drugs for their imminent use in breast cancer drug delivery system. Effects of TTDPM, CM and their

 

complexes with MTX were studied for MTX release in phosphate buffer saline (pH 7.4) + 10% DMSO and phosphate buffer saline (pH 7.4) respectively.

 

 

 

 

 

 

 

 

H3C

 

 

 

 

CH3

 

H2C

H2C                          CH2

 

CH2

 

O                O

C C

O CH O

O C

H C

 

 

 

 

CH3

 

OH

H2C

O

 

OH

H2C

O

O

 

OH

H2C

O

O

HO

 

3 CH2 O

H2C O

 

H2C

O H2C

 

HO                                HO

 

RT,

24 h

O O OH

NH2

N H

N

O

N                             N

 

N N

NH2                              NH                                  NH

 

 

C     C                  C C O

 

O     C           n            O    C

 

CH   O      O     CH

 

C O O

CH2 H2C

H3C

 

O C O

CH2 CH2 CH3

 

HC NH2 H2C

CH2

S

CH3

 

OH

 

CH3

 

Dendrimer (TTDPM)

 

 

H3C

 

 

 

 

H2N

 

 

 

MTX

 

Chitosan Derivative (CM)

 

H2C

 

CH3

Interaction Electrostatic

Interaction

Text Box: Interaction Electrostatic
Interaction
CH

 

 

 

N NH2

 

H2C

O

 

2

CH2

O

 

 

O OH OH

 

 

 

OH                                 OH                                 OH

 

H2N N N

N N

 

 

OO

HN OH

 

C              C                                              O

HC                                                            N          O

O                         O                                              H

C                      HHN   N   N

 

H2C

 

HO

 

H2C

O

O

HO

 

H2C

O                                    O

O

HO

 

OH O

 

N N N

 

NH2                              NH                                  NH

 

O

 

H C H C

 

H2N

 

 

CH2

 

CH3

 

O    C                            O    C

OH                    HC                                    CH

 

3              2   H C                  O

 

O                         CH2

 

OH                                          NH2                            3

 

2 O

C              C

HC               O

 

O

C                HC

O               HC

 

 

O OH OH

 

O              O

O NH

 

H2C

 

 

CH2

 

OH   OH

O              O

 

C O HO OH

O                             OH

HN O

CH                        O

 

O                                                      NH O

CH

 

O H2N N N

N       N

 

 

 

 

O

 N

H2N   N

N

N  N

H N

 

 

S

CH3

H2N N

 

O NH

 

N

 

N

 

2                                                    CH2 N

H N

 

2                                                               N N

 

H2C

H3C

 

N

 

N   N

N N NH2 H2N

 

2

H2C

CH3

 

H2N

 

MTX-Dendrimer Complex

 

MTX-Chitosan Derivative

 


Author(s): Reena Tondwal and Man Singh

Abstract | PDF

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