One major pathogenesis of obesity is the unbalanced hormones,too much stress hormone steroid and/or not enough“anti-obese” happy hormones, endorphin, serotonin, dopamine,and oxytocin, too much estrogen and/or too less testosterone.If everybody loves his/her love, it may be better balanced. Yet,the reality is the reality. LGBT healthcare remains far behind.As an unresolved frustration, closeted homosexuality causes aseries of health problems, obesity, tobacco/alcohol/substanceabuse, and mental/psychiatric disorders. Incautious sexualpractice causes sexual transmitted diseases (STDs) like AIDS.Social problems like inequality opportunities among minoritieshappen often. It brought huge challenge for management.Better acceptance and recognition from learning in a varietyway, information merged into clinical visits through smartphoneapps and electronic medical record system (ERMS), barrierprotection in sexual practice, positive attitude in daily life,team network of physicians, psychiatrists, psychologists, pharmacists,activists, and communities, with loving hearts. Startlocal, go global, don’t ever shut the door.