Abstract

Long Term Outcome of Childhood Steroid?? Sensitive Nephrotic Syndrome

The longâ??term outcome of childhood steroidâ??sensitive nephrotic syndrome (SSNS) needs further evaluation. In this study, In this study, we report the longâ??term outcome of childhood SSNS at our center. Patients and Methods: This is a retrospective review of cohort of children with SSNS followed by crossâ??sectional followâ??up evaluation. We included all children aged ≥16 years with a history of childhood SSNS. Of 45 children diagnosed with SSNS and contacted for followâ??up, only 9 children were available for evaluation of longâ??term outcome. Demographic, socioeconomic, and disease history data were collected through a questionnaire. All the patients were examined and had their urine and blood samples collected for investigations. The data were analyzed using SPSS. Results: The mean age at onset for the 45 children was 7.3 ± 3.9 years. Followâ??up revealed that 65.1% had frequent relapsing or steroidâ??dependent nephrotic syndrome and 34.9% had infrequent relapses. Of nine patients were included in the followâ??up study for a median (range) duration of 11 (5–18) years, 2 of the patients were relapsing at the time of the study and two had one or more relapses during the previous year. Estimated glomerular filtration rate (eGFR) declined in two children and the mean eGFR for the whole group was lower at the time of last followâ??up than at baseline (P = 0.032). Conclusion: Children with SSNS need careful longâ??term monitoring of disease activity and kidney function. A larger prospective study is required.


Author(s): Nada Kalakattawi 

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