Cancer occurs mostly in the developing countries. Epidemiological studies that evaluate risk factors are important for prognosis and prevention. Journal of Cancer Epidemiology and Prevention reports the ways and means of assessing the cause of cancer, its development trend and its control/prevention. The current issue includes signaling pathways relevant to cancer, effect of traditional medicine on liver cancer, adequacy of minorities’ representation in clinical trials, a review on endometrial carcinoma diagnosis and collation of tumor related data as study tool. Intracellular signaling pathways include cyclic nucleotides such as cAMP, Ca2+, and Ca2+ channels. Mutations of genes causes deregulation of these pathways leading to growth and dissemination of cancer cells. Errante et al.  reviewed the role of Ca2+ channels and cyclical nucleotides like cAMP in cancer initiation and growth and suggested that the use of Ca2+ channel blockers might modify tumor growth and modifiers of cAMP production might decrease anti-tumor resistance. Liver cirrhosis is the risk factor for liver cancer. Based on a population study comprising of 8145 liver cirrhosis patients, Chen et al. , have observed a strong association between the use of traditional Chinese herbal medicines and liver cancer among men. Disproportionately higher incidence of cancer was noted in certain ethnic and racial groups in US.