E-Health is seen as the application of modern information and communication technology to advance or facilitate healthcare. People are more likely to search on social media (49%) than to see their doctors (11%) when they have healthcare problems. A special group of active social media users have appeared and started to gain attention in these years. They are not medical professionals but use social platforms to disseminate health information, create health awareness and provide health solutions to their target audiences. These so-called social media influencers have established a positive rapport with their audience. The main aim of this study is to investigate the diabetes narratives that have been presented by social media influencers (SMIs) because SMIs bring a new dimension for communicating health information with the potentially improving health outcomes. 10 social media influencers in the UK are defined in this study. Their existing diabetes narratives on social media and the impacts of those narratives on audiences’ health attitudes and behaviour are analysed through qualitative and quantitative methods, including frame (content-level) and discourse (language-level) features. Moreover, a comparative analysis of questionnaire data on audiences’ perception and perceived trustworthiness is conducted to investigate the effectiveness of SMIs in influencing their followers and non-followers.