Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. A cancer that forms in the cells of the breasts is known as Breast Cancer. Breast cancer is the most common invasive cancer in women and the second leading cause of cancer death in women after lung cancer. The coumarin is well known naturally occurring heterocyclic compound having wide range of medicinal properties. The furo-fused coumarin is one of fused derivative of coumarin having various activities along with anti-tumor. Various furo-fused derivatives of coumarin have been found active against breast cancer. The synthesis of nitroethenes and their condensation with 4-hydroxy coumarins results in furofused coumarins. These synthesized compounds were screened for anti-cancer activity by cell viability study against Breast Cancer Cell Line (Michigan Cancer Foundation-7).