Introduction: metabolic syndrome is a constellation of altered parameters that coexist with obesity increasing risks for cardiovascular disease.
Objective: To evaluate 1) the effects of the clinical multicomponent therapy in the prevalence of metabolic syndrome; and 2) if the leptin and adiponectin can modulate its response in women with obesity.
Methods: Interdisciplinary therapy consisted of follow-up with an endocrinologist, nutritionist, and exercise physiologist, associated with health education by web-based weekly videos about exercise and nutrition to promote lifestyle changes (# 12semanas®) and support through Facebook®, Instagram® and WhatsApp®. This study can be approved by the Research Ethics Committee. Women with obesity (n = 32), aged 31.06 ± 4.70 years and BMI of 34.01 ± 4.00 kg/m² were selected. Body composition by electric bioimpedance and adiponectin, leptin by ELISA were performed. The metabolic syndrome screening was made by IDF criteria.
Results: At the beginning of therapy 21.8% of women with obesity present metabolic syndrome (MS) diagnosis wich was reduced to 3%. In the delta comparison, MS group presented higher values for body weight, waist circumference, body fat, total cholesterol, and reduced HDL-c. Improvements were finding in body composition and lipid profile in both analysed groups. In the MS group it were observed a reduction in the leptin concentration. Delta comparison finding a positive correlation between leptin/adiponectin ratio with waist circumference and HOMA-AD.
Conclusion: Clinical approach associated with health education was effective in reducing the MS prevalence mediated by leptin and adiponectin avoid the development of cardiovascular disease in women with obesity.