This paper would like to investigate Shakespeare’s Macbeth and Sophocles’ King Oedipus in the light of genetic disorders. Playwrights are of two different ages and two different countries. One is a British dramatist and another a Greek dramatist. Both of them have differences in many respects, like theme, style, setting, and scene. So, this paper wants to examine Shakespeare’s and Sophocles’ the two texts based on the reasons of genetically mental disorders of characters. It proposes to incorporate a wide variety of related but diverse and even contradictory situations, focusing on anxiety disorders, hyperactivity disorder, compulsive disorder, panic disorder, schizophrenia, social anxiety phobia, dissociative identity disorder, female sexual arousal disorder, sleep terror disorder, and sleepwalking disorder, which are originated from the human gene.