R.Ejoba,B. A. Utu-Baku, R. U. Ukpanukpong, K. Dasofunji, M. N. Ugwu, A. A. Abong and R. N. Uyabeme
The effect of Saccharum barberi extract on lipid profile level was investigated in albino wistar rats. Forty albino wistar rats of male sex were randomly assigned into four study groups of ten animals each to give in all four study groups of male wistar rats respectively. Graded doses of the alcoholic extracts 100mg/kg, 200mg/kg and 300mg/kg body weight in normal saline were administered to the treatment groups II, III and IV via orogastric tube; the control group I received placebo (normal saline) for 21 days. At the end of 21 days experimental period, the animals Albino wistar rats were fasted overnight and weighed. The animals were anaesthetized in chloroform vapor and dissected and blood collected from the jugular vein using sterilized syringe and needle. Data generated showed that at 200mg/kg and 300mg/kg dose regimen, the impact of the extract on serum lipid profile showed a significant decrease in total cholesterol, low density lipoprotein and triacylglycerols, with an attendant increase in high density lipoprotein in Albino wistar rats, thereby reducing atherosclerosis risk.
