Diabetic Nephropathy remains the leading cause of ESRD in western countries. It is considered as microvascular complication occurring in both Type 1 DM and Type 2 DM. 30%-40% of patients with diabetes are prone to develop Diabetic nephropathy. In clinical practice, some of the individuals suffering from diabetes are not tend to develop diabetic kidney disease, even if their glucose is not strictly controlled. However some individuals with perfect glycemic conditions tend to develop ESRD.