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Abstract

E-BABE-Encyclopedia of Bioanalytical Methods for Bioavailability and Bioequivalence Studies of Pharmaceuticals

Encyclopedia of Bioanalytical Methods for Bioavailability and Bioequivalence Studies of Pharmaceuticals (E-BABE): It is a unique
encyclopedia involving bioanalytical methods for bioavailability and bioequivalence (BA/BE) studies of pharmaceuticals for
suitable method selection with thousands of combinations and searches against these methods. Most scrutinized literature was
collected from different sources including PubMed. This database has been curetted using published methods for all most all
pharmaceuticals. Required information for regular method development/validation such as IUPAC name, structure, solubility,
chromatographic conditions, instrumentation information like HPLC, LCMS detection parameters, sample preparations,
recovery details, limit of detection and limit of quantification, Tmax, Cmax etc., for routine application in BA/BE studies of
pharmaceuticals was incorporated including official pharmacopeias information such as European Pharmacopeia, Japan
Pharmacopeia and US Pharmacopeia. Database includes drug based bioanalytical methods covering most required fields and
external database links of important drug portals such as drug bank, Rxlist, MEDLINE plus, KEGG Drug ID, KEGG Compound ID,
Merck manual, PubChem compound ID, PubChem substance ID and USFDA. Searching/querying the database is through drug
name, chemical formula or structural search by smiles format. Keen selections of bioanalytical methods for pharmaceutical
analysis or regular quality control are also possible with E-BABE. E-BABE was built understanding the needs of pharmaceutical
industry and laboratories including CROs working on BA/BE studies.


Author(s): Assoc Prof. Navaneeth A T

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