Hepatocellular carcinoma (HCC) is an extremely rare tumour during pregnancy. HCC during pregnancy has a poor outcome and 20% of patients have distant metastasis at presentation according to previous reports. Malignancies should be carefully approached and considered as differential diagnoses in pregnant women. We present a case of a pregnant female with HCC associated with hepatitis B infection expressing biliary immunophenotype. Hepatocellular carcinoma (HCC) is an important, rare entity during pregnancy.