Cholera is an acute diarrheal disease mainly endemic in low income countries. The present study was made to develop the cell envelope protein (CEPs) loaded sodium alginate/HPMC microcapsules for oral controlled vaccine delivery. The alginate/HPMC microcapsules were prepared by ionic gelation technique with different polymer/protein ratio and evaluated. The morphology was evaluated in different physical states (fully swollen, dried & reswollen) and the particle size remains same for all formulations. The Swelling studies indicated the increase of swelling behavior after addition of HPMC. The protein release profile has indicated that the addition of HPMC increases the release rate. According to release kinetics applied for various formulations, kinetics was varied between zero order release and higuchi kinetics.