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Clear Cell Renal Carcinoma Synchronous with Dedifferentiated Liposarcoma

Background: multiple primary malignant neoplasms are not
frequent but are increasing in incidence, some of them are associated
with genetic syndromes like Von Hippel-Lindau and
Li-Fraumeni. Dedifferentiated liposarcoma is one of the rarest
soft tissue tumors and clear cell renal carcinoma is the most
frequent kidney cancer. The concomitant presence of these
tumors is extremely rare, however, there have been some cases
reported, none of them presenting with a liposarcoma of
the limbs. This report looks to expose an interesting case of a
synchronous multiple primary tumors patient presenting with
a very rare liposarcoma associated with a renal cell carcinoma
(a very rare association). A review of the literature and a collection
of similar cases published previously are also provided.
Case presentation: here we expose the case of a 62-year-old,
Hispanic man who presents with a left thigh mass compatible
with dedifferentiated liposarcoma which was synchronous
with a metastatic clear cell renal carcinoma. Multiple treatment
lines were provided with no response, with a further metastatic
transformation. Genetic analysis by liquid biopsy showed some
mutations that were not susceptible of targeted therapy. At the
time of this report the patient is undergoing palliative care as
he persists with a non-responsive metastatic disease.
Conclusions: we present the first case reported of a clear cell
renal carcinoma synchronous to a dedifferentiated liposarcoma
of a limb. The association between renal cell carcinoma and dedifferentiated
liposarcoma is unusual and there are few reports
in the literature. More research about these tumors along with
genetic tests need to be performed looking for a better understanding
of the fundamental basis of this rare association.

Author(s): Juan Esteban Garcia-Robledo

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