Water insufficiency and wastewater generation is the major anxiety that impacts the livelihood. Renewable water used for irrigation is long-term experience in developed and developing country. However, in developing country the volume of treating and using wastewater is limited due to the lack of adequate data, knowledge, and improper management. Wastewater is an important source of water and nutrients for irrigation in developing countries. It can be used as reclaimed water and applied directly to crops or indirectly after discharge and dilution with water from rivers or reservoirs. Undesirable constituents in wastewater can harm human health and the environment. For different reasons, developing countries are still unable to implement comprehensive wastewater treatment programs. This paper evaluation of wastewater irrigation in developing countries, endorse strengthening institutional capacity and establishing links between waste generators and sanitation sectors through inter institutional coordination leads to more efficient management of wastewater and risk reduction.