Rafeeq Alam Khan, Afshan Siddiq and Sadia Ghousia Baig
Introduction: Blood pressure, serum cholesterol and glucose levels are the age associated risk factors necessary to screen for controlling cardiovascular disorder. Multiple mediators are involved in pathogenesis of disease by different mechanisms. To target those pathological conditions multiple medicines yield is better therapeutic approach. Multi drug therapy for the management of multiple disorders among younger has different strategy than in elderly as many drugs may be less effective or less suitable for elderly patients. To minimize the risk of multiple drug administration associated toxicity treatment plans should to adjust accordingly.
Objective: Drug interactions are of great concern because doctors and patients are usually unaware of toxicities due to simultaneous administration of drugs. Investigate of safe combinations should be necessary approach which are less likely to interact with each other. Several studies have been conducted previously to observe the toxic effects associated with the use of numerous combinations.
Method: In present study toxic effects on renal function were assessed following administration of individual and combination of drugs to rabbits for the period of two months. Renal function tests were done by using kit method and all values were compared with control by taking mean and standard error to the mean using one-way analysis of variance (ANOVA) followed by post hoc.
Results: Results of this study revealed that animals received individual drugs acarbose and glibenclamide and combination of metformin-amlodipine and atorvastatin showed significant decrease (p<0.005) in urea as compared to control rabbits. However animals received individual drugs lisinopril and losartan and combination of glibenclamide, losartan and Atorvastatin showed significant increase (p <0.005) in urea as compared to control animals.
Conclusion: Present study revealed significant nephrotoxicity with poor kidney function in animals received combination of glibenclamide, losartan and atorvastatin, hence it may be suggested that this combination should be avoided in patients with compromised renal function and if is necessary than should be taken under proper medical supervision.
